The earliest eunuch interference in Chinese history should be Zhao Gao in the Qin Dynasty. Through means such as forgery of decrees, he made the eldest son of Emperor Qin Shi Huang, Fusu, commit suicide, and Hu Hai ascended the throne as Qin Ershi. Later, relying on the favor and trust of Qin Ershi, he used his power status to interfere in politics, and then further expanded his power, even having a certain degree of imperial power, and brutally oppressing and conscripting the people. He also plotted to frame Li Si, causing Li Si to be executed. In the end, the Qin Dynasty fell, and Zhao Gao was also overturned for his crimes and punished with the punishment of wiping out three generations of his family.

In addition to the Qin Dynasty, there were also cases of eunuch interference in the Eastern Han Dynasty, Tang Dynasty, Ming Dynasty and other dynasties in Chinese history.

During the Eastern Han Dynasty, eunuch interference reached its climax and became a contradiction within the country. In the Tang Dynasty, especially during the late Tang period, eunuchs also frequently interfered in politics, seriously undermining the stability of court politics.

In the early Ming Dynasty, the status of eunuchs was not high, and Emperor Zhu Yuanzhang had also ordered that eunuchs were not allowed to participate in politics. However, over time, eunuchs gradually accumulated power. During the reign of Emperor Zhu Di of the Ming Dynasty, eunuchs actually had control over the power of the Eastern Factory and became one of the actual power holders in the court. The Eastern Factory became a tool specifically used by eunuchs to suppress political opponents and safeguard their own interests.

During the reign of Emperor Xianzong of the Ming Dynasty, in order to strengthen control over officials, the Western Factory was established, and together with the Eastern Factory, they constituted the eunuch's supervisory, judicial, and law enforcement agencies, further expanding the power of eunuchs. During this period, eunuchs could arrest ministers and civilians at will, conduct trials, and at the same time monitor officials and interfere in court politics. The eunuch interference in the later period of the Ming Dynasty had seriously eroded the authority and stability of the court, becoming one of the important reasons for the fall of the Ming Dynasty.

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